Cardio-CARE AG was founded by the Kühne Foundation in January 2020 to strengthen expertise in the field of data science at the Davos Medical Campus. Essential for success in this environment of bioinformatics and biostatistics is the networking with other research institutions and research groups, such as the Graubünden-based Academia Raetica and the Swiss Institute of Bioinformatics (SIB). A very close link exists with the University Medical Center Hamburg-Eppendorf (UKE), where an endowed professorship for Prof. Dr. Raphael Twerenbold is located in the Department of Cardiology through funding from the Kühne Foundation.
The supporting pillar for Cardio-CARE is the currently largest whole-genome sequencing project in the German-speaking countries. In a multidisciplinary collaboration with the Clinic of Cardiology of the UKE as well as the Institute of Pathology of the University Hospital Zurich (Switzerland), the whole genome of more than 9000 individuals has been sequenced. About 8000 of the individuals have been studied as representative sample from the Hamburg population in the Hamburg City Health Study (HCHS). The other just over 1000 individuals have very specific heart disease, suggesting an influence of genetics on heart disease.
The goal of the project is to better understand the genetic basis of cardiovascular disease, improve diagnostics, and identify targets for treatment. In addition, Cardio-CARE is involved in other projects to improve diagnostics and treatment of cardiovascular disease. In these areas, Cardio-CARE successfully uses artificial intelligence techniques.
All bioinformatic and biostatistical analyses of this project are performed at Cardio-CARE in Davos using its own high-performance computer.